What is our Estrobolome and how it’s linked to Endometriosis

Feb 20, 2021 | Health & Wellbeing, Hormones

New research has emerged indicating the gut micro-biome plays an integral role in the regulation of oestrogen levels within our body. This is key when it comes to endo and estrogen metabolism. 

To optimise homeostasis within the gut we need to have a healthy functioning gut.  
When our gut health and micro-biome is balanced we absorb nutrients from our food helping regulate intestinal permeability, optimising the immune system and regulating oestrogen levels. Gut symbiosis is essential to creating a healthy eco-system. 

When inflammation exists within in the gut it starts to wreak havoc creating systemic inflammatory responses. The body enters into high alert- promoting disease and hormone dysfunction, altering the bodies immune response and increasing levels of circulating oestrogen.

In the case of endometriosis, increased estrogen exposure stimulates growth of ectopic tissue and causes an inflammatory response within the cells. Not what we need! This is where the term estrobolome comes in. The estrobolome is a term used to describe the collection of enteric (gut) bacterial microbes. Their job is to metabolise oestrogen. These microbes (Estrobolome) produce beta-glucuronidase. This enzyme alters estrogen into it’s active form, which bind to oestrogen receptors and influence oestrogen-dependent physiological processes. Essentially the more your gut is out of balance (dysbiosis), the more beta-glucuronidase is produced, and the less oestrogen is excreted out of your body. The estrobolome of women with endometriosis – research has shown they have larger numbers of beta-glucuronidase bacteria leading to increased circulation of oestrogen. How to balance your Estrobolome:

📍Supplementation with a broad spectrum lactobacillus probiotic has found to normalise microbes in both the gut and female reproductive tract and decrease bacteria that produce beta-glucuronidase
📍No alcohol
📍Cruciferous vegetables such as cabbage, broccoli, cauliflower, kale help regulate gut bacteria, supporting and detoxing of oestrogen

Amanda is the founder of Angea and has over 12 years of experience working with women to support their health journey. In addition to being a registered doctor of Chinese medicine, Amanda is a yoga teacher and founder of Mindful Pregnancy Yoga Training. Amanda offers acupuncture, Chinese herbal medicine and womb healing treatments at Angea.